Personalized management of pheochromocytoma and paraganglioma
S Nölting, N Bechmann, D Taieb… - Endocrine …, 2022 - academic.oup.com
Pheochromocytomas/paragangliomas are characterized by a unique molecular landscape
that allows their assignment to clusters based on underlying genetic alterations. With around …
that allows their assignment to clusters based on underlying genetic alterations. With around …
Pheochromocytoma and paraganglioma
HPH Neumann, WF Young Jr… - New England journal of …, 2019 - Mass Medical Soc
Pheochromocytoma and Paraganglioma Pheochromocytoma and paraganglioma are
related tumors that differ mainly in location; pheochromocytomas are adrenal, and …
related tumors that differ mainly in location; pheochromocytomas are adrenal, and …
An overview of 20 years of genetic studies in pheochromocytoma and paraganglioma
A Buffet, N Burnichon, J Favier… - Best practice & research …, 2020 - Elsevier
Paragangliomas and pheochromocytomas (PPGL) are rare neuroendocrine tumours
characterized by a strong genetic determinism. Over the past 20 years, evolution of PPGL …
characterized by a strong genetic determinism. Over the past 20 years, evolution of PPGL …
Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands
Precise deposition of CpG methylation is critical for mammalian development and tissue
homeostasis and is often dysregulated in human diseases. The localization of de novo DNA …
homeostasis and is often dysregulated in human diseases. The localization of de novo DNA …
The North American Neuroendocrine Tumor Society consensus guidelines for surveillance and management of metastatic and/or unresectable pheochromocytoma …
L Fishbein, J Del Rivero, T Else, JR Howe, SL Asa… - Pancreas, 2021 - journals.lww.com
This manuscript is the result of the North American Neuroendocrine Tumor Society
consensus conference on the medical management and surveillance of metastatic and …
consensus conference on the medical management and surveillance of metastatic and …
The diagnosis and clinical significance of paragangliomas in unusual locations
Paragangliomas are neuroendocrine neoplasms, derived from paraganglia of the
sympathetic and parasympathetic nervous systems. They are most commonly identified in …
sympathetic and parasympathetic nervous systems. They are most commonly identified in …
Genotype–phenotype correlations in pheochromocytoma and paraganglioma: a systematic review and individual patient meta-analysis
Pheochromocytoma and paraganglioma (PPGL) can be divided into at least four molecular
subgroups. Whether such categorizations are independent factors for prognosis or …
subgroups. Whether such categorizations are independent factors for prognosis or …
Positive impact of genetic test on the management and outcome of patients with paraganglioma and/or pheochromocytoma
A Buffet, L Ben Aim, S Leboulleux, D Drui… - The Journal of …, 2019 - academic.oup.com
Abstract Context Pheochromocytomas and paragangliomas (PPGLs) are characterized by a
strong genetic component, with up to 40% of patients carrying a germline mutation in a …
strong genetic component, with up to 40% of patients carrying a germline mutation in a …
A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
G Sendžikaitė, CW Hanna, KR Stewart-Morgan… - Nature …, 2019 - nature.com
DNA methyltransferases (DNMTs) deposit DNA methylation, which regulates gene
expression and is essential for mammalian development. Histone post-translational …
expression and is essential for mammalian development. Histone post-translational …
Mechanisms of chromatin-based epigenetic inheritance
Multi-cellular organisms such as humans contain hundreds of cell types that share the same
genetic information (DNA sequences), and yet have different cellular traits and functions …
genetic information (DNA sequences), and yet have different cellular traits and functions …