Contribution of adipogenesis to healthy adipose tissue expansion in obesity
L Vishvanath, RK Gupta - The Journal of clinical …, 2019 - Am Soc Clin Investig
The manner in which white adipose tissue (WAT) expands and remodels directly impacts the
risk of developing metabolic syndrome in obesity. Preferential accumulation of visceral WAT …
risk of developing metabolic syndrome in obesity. Preferential accumulation of visceral WAT …
Modelling metabolic diseases and drug response using stem cells and organoids
Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …
major threat to health in the modern world, but efforts to understand the underlying …
In vitro and ex vivo models of adipocytes
Adipocytes are specialized cells with pleiotropic roles in physiology and pathology. Several
types of fat cells with distinct metabolic properties coexist in various anatomically defined fat …
types of fat cells with distinct metabolic properties coexist in various anatomically defined fat …
Modeling adipogenesis: current and future perspective
Adipose tissue is contemplated as a dynamic organ that plays key roles in the human body.
Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells …
Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells …
Microenvironmental control of adipocyte fate and function
The properties of tissue-specific microenvironments vary widely in the human body and
demonstrably influence the structure and function of many cell types. Adipocytes are no …
demonstrably influence the structure and function of many cell types. Adipocytes are no …
Maternal obesity and programming of metabolic syndrome in the offspring: searching for mechanisms in the adipocyte progenitor pool
TB Scheidl, AL Brightwell, SH Easson, JA Thompson - BMC medicine, 2023 - Springer
Background It is now understood that it is the quality rather than the absolute amount of
adipose tissue that confers risk for obesity-associated disease. Adipose-derived stem cells …
adipose tissue that confers risk for obesity-associated disease. Adipose-derived stem cells …
Visceral adipose tissue Tregs and the cells that nurture them
C Li, RG Spallanzani, D Mathis - Immunological Reviews, 2020 - Wiley Online Library
Visceral adipose tissue (VAT) is a primary site for storage of excess energy, but it also
serves as an important endocrine organ that impacts organismal metabolism. Chronic, low …
serves as an important endocrine organ that impacts organismal metabolism. Chronic, low …
3D collagen microfibers stimulate the functionality of preadipocytes and maintain the phenotype of mature adipocytes for long term cultures
Although adipose tissue is one of the most abundant tissues of the human body, its
reconstruction remains a competitive challenge. The conventional in vitro two or three …
reconstruction remains a competitive challenge. The conventional in vitro two or three …
[HTML][HTML] Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue
Objective Studies in mice have shown that the decrease in lipoprotein lipase (LPL) activity in
adipose tissue upon fasting is mediated by induction of the inhibitor ANGPTL4. Here, we …
adipose tissue upon fasting is mediated by induction of the inhibitor ANGPTL4. Here, we …
Mesothelial cells are not a source of adipocytes in mice
Visceral adipose tissue (VAT) depots are associated with the adverse metabolic
consequences of obesity, such as insulin resistance. The developmental origin of VAT …
consequences of obesity, such as insulin resistance. The developmental origin of VAT …