[HTML][HTML] Current and emerging target identification methods for novel antimalarials
New antimalarial compounds with novel mechanisms of action are urgently needed to
combat the recent rise in antimalarial drug resistance. Phenotypic high-throughput screens …
combat the recent rise in antimalarial drug resistance. Phenotypic high-throughput screens …
Redox-based strategies against infections by eukaryotic pathogens
C Vallières, MP Golinelli-Cohen, O Guittet, M Lepoivre… - Genes, 2023 - mdpi.com
Redox homeostasis is an equilibrium between reducing and oxidizing reactions within cells.
It is an essential, dynamic process, which allows proper cellular reactions and regulates …
It is an essential, dynamic process, which allows proper cellular reactions and regulates …
Dietary aflatoxin B1 and antimalarial—a lumefantrine/artesunate—therapy perturbs male rat reproductive function via pro-inflammatory and oxidative mechanisms
We investigated the impact of Coartem™(COA) and aflatoxin B1 (AFB1) on rats'
hypothalamus, epididymis, and testis. Male rats were randomly grouped (n= 5 rats) and …
hypothalamus, epididymis, and testis. Male rats were randomly grouped (n= 5 rats) and …
Access to Artemisinin–Triazole Antimalarials via Organo-Click Reaction: High In Vitro/In Vivo Activity against Multi-Drug-Resistant Malaria Parasites
L Herrmann, M Leidenberger, HC Quadros, BW Grau… - JACS Au, 2024 - ACS Publications
Malaria is one of the most widespread diseases worldwide. Besides a growing number of
people potentially threatened by malaria, the consistent emergence of resistance against …
people potentially threatened by malaria, the consistent emergence of resistance against …
[HTML][HTML] Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy
New antimalarial drug candidates that act via novel mechanisms are urgently needed to
combat malaria drug resistance. Here, we describe the multi-omic chemical validation of …
combat malaria drug resistance. Here, we describe the multi-omic chemical validation of …
Lewis acids and heteropoly acids in the synthesis of organic peroxides
IA Yaremenko, PS Radulov, YY Belyakova… - Pharmaceuticals, 2022 - mdpi.com
Organic peroxides are an important class of compounds for organic synthesis,
pharmacological chemistry, materials science, and the polymer industry. Here, for the first …
pharmacological chemistry, materials science, and the polymer industry. Here, for the first …
Recent metabolomic developments for antimalarial drug discovery
L Mamede, F Fall, M Schoumacher, A Ledoux… - Parasitology …, 2022 - Springer
Malaria is a parasitic disease that remains a global health issue, responsible for a significant
death and morbidity toll. Various factors have impacted the use and delayed the …
death and morbidity toll. Various factors have impacted the use and delayed the …
Bibliometric analysis of antimalarial drug resistance
Background Malaria has always been a serious infectious disease prevalent in the world.
Antimalarial drugs such as chloroquine and artemisinin have been the main compounds …
Antimalarial drugs such as chloroquine and artemisinin have been the main compounds …
Artefenomel regioisomer RLA-3107 is a promising lead for the discovery of next-generation endoperoxide antimalarials
BR Blank, J Gut, PJ Rosenthal… - ACS Medicinal Chemistry …, 2023 - ACS Publications
Clinical development of the antimalarial artefenomel was recently halted due to formulation
challenges stemming from the drug's lipophilicity and low aqueous solubility. The symmetry …
challenges stemming from the drug's lipophilicity and low aqueous solubility. The symmetry …
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy
New antimalarial drug candidates that act via novel mechanisms are urgently needed to
combat malaria drug resistance. Here, we describe the multi-omic chemical validation of …
combat malaria drug resistance. Here, we describe the multi-omic chemical validation of …