Motivated by the pressing need to characterize protein–DNA and protein–RNA interactions
on large scale, we review a comprehensive set of 30 computational methods for high …

A key challenge of modern biology is to uncover the functional role of the protein entities that
compose cellular proteomes. To this end, the availability of reliable three-dimensional …

Understanding the molecular mechanism of protein–RNA recognition and complex
formation is a major challenge in structural biology. Unfortunately, the experimental …

Protein-DNA and protein-RNA interactions are part of many diverse and essential cellular
functions and yet most of them remain to be discovered and characterized. Recent research …

Motivation Accurate predictions of protein-binding residues (PBRs) enhances understanding
of molecular-level rules governing protein–protein interactions, helps protein–protein …

Sequence-derived structural and physicochemical features have been extensively used for
analyzing and predicting structural, functional, expression and interaction profiles of proteins …

Proteins form large macromolecular assemblies with RNA that govern essential molecular
processes. RNA-binding proteins have often been associated with conformational flexibility …

Motivation Detection of RNA-binding proteins (RBPs) is essential since the RNA-binding
proteins play critical roles in post-transcriptional regulation and have diverse roles in various …

Protein-RNA interactions are central to essential cellular processes such as protein
synthesis and regulation of gene expression and play roles in human infectious and genetic …

The interactions between proteins and nucleic acid sequences play many important roles in
gene expression and some cellular activities. Accurate prediction of the nucleic acid binding …