Superoxide, O2•−, is formed in all living organisms that come in contact with air, and,
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …

Publisher Summary This chapter discusses the role of free radicals and catalytic metal ions
in human disease. The importance of transition metal ions in mediating oxidant damage …

Mimicking the coordination geometry of the active metal sites of natural enzymes is an
efficient strategy in designing therapeutic chemicals with enzymelike in vivo reaction …

Superoxide dismutases Page 66 SUPEROXIDE DISMUTASES By IRWIN FRIDOVICH,
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina …

If direct chemical reactions of 0; are unlikely to account for most of the damage done by
aqueous O;-generating systems, then what does? Singlet Oz is an unlikely candidate-there …

The discovery of superoxide dismutases (SODs), which convert superoxide radicals to
molecular oxygen and hydrogen peroxide, has been termed the most important discovery of …

During its reduction to water, O2 readily gives rise to dangerously reactive intermediates.
This threat is diminished by families of defensive enzymes which include the superoxide …

The study of superoxide dismutase (SOD)(EC 1.15. 1.1) started almost half a century ago
when the copper known to be present in blood was found to be associated with a protein …

1.2. Hydrogen Peroxide 1.3. Hydroxyl Radical and HO 2. Radical 1.4. Hydroxyl Radical
Production in Superoxide-Generating and Other Biological Systems

Superoxide dismutases (SOD) are considered to be antioxidant enzymes. This view came
about because its substrate, superoxide, is a free radical; in the era of their discovery, 1960's …