Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …

In the current era of modern drug design & development via computer-aided drug design,
the potential role of computational software tools is widely enlarged in use. Computer-based …

We present a series of databanks (http://swift. cmbi. ru. nl/gv/facilities/) that hold information
that is computationally derived from Protein Data Bank (PDB) entries and that might …

FoldX is an empirical force field that was developed for the rapid evaluation of the effect of
mutations on the stability, folding and dynamics of proteins and nucleic acids. The core …

Abstract The Protein Data Bank (PDB) is the world-wide repository of macromolecular
structure information. We present a series of databases that run parallel to the PDB. Each …

One of the conclusions drawn at the CASP4 meeting in Asilomar was that applying various
force fields during refinement of template‐based models tends to move predictions in the …

Today's energy functions are not able yet to distinguish reliably between correct and almost
correct protein models. Improving these near‐native models is currently a major bottle‐neck …

Abstract Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF
complexes, contributes to a range of malignancies and neurologic disorders. Unfortunately …

A growing number of proteins are being identified that are biologically active though
intrinsically disordered, in sharp contrast with the classic notion that proteins require a well …

Abstract The 19th annual Database Issue of Nucleic Acids Research features descriptions of
92 new online databases covering various areas of molecular biology and 100 papers …