Sulfur is an essential element for microorganisms and it can be obtained from varied
compounds, sulfate being the preferred source. The first step for sulfate assimilation, sulfate …

Mycobacterium tuberculosis is a prototrophic, metabolically flexible bacterium that has
achieved a spread in the human population that is unmatched by any other bacterial …

Mycobacterium bovis is the causative agent of tuberculosis in a range of animal species and
man, with worldwide annual losses to agriculture of $3 billion. The human burden of …

The majority of individuals infected with TB develop a latent infection, in which organisms
survive within the body while evading the host immune system. Such persistent bacilli are …

Multidrug resistance, strong side effects, and compliance problems in TB chemotherapy
mandate new ways to kill Mycobacterium tuberculosis (Mtb). Here we show that deletion of …

Mycobacterium tuberculosis remains the predominant bacterial scourge of mankind.
Understanding of its biology and pathogenicity has been greatly advanced by the …

Background Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects
approximately 2 billion people worldwide and is the leading cause of mortality due to …

The growth and nutritional requirements of mycobacteria have been intensively studied
since the discovery of Mycobacterium tuberculosis more than a century ago. However, the …

Large-scale proteomic analyses in Escherichia coli have documented the composition and
physical relationships of multiprotein complexes, but not their functional organization into …

The identification of new antibacterial targets is urgently needed to address multidrug
resistant and latent tuberculosis infection. Sulfur metabolic pathways are essential for …