Background Severe trauma represents a major global public health burden and the
management of post-traumatic bleeding continues to challenge healthcare systems around …

Hemorrhage after trauma remains a significant cause of preventable death. Trauma-induced
coagulopathy (TIC) at the time of hospital admission is associated with an impaired …

Current trauma-induced coagulopathy resuscitation protocols use slow laboratory
measurements, rules-of-thumb, and clinician gestalt to administer large volumes of …

Guidelines for the treatment of severe bleeding comprise viscoelastic-test-guided use of
coagulation factor concentrates as part of their recommendations. The aim of this study is to …

Plasma is overused as a blood product worldwide; however, data supporting appropriate
use of plasma is scant. Its most common utilization is for treatment of coagulopathy in …

Purpose The 5 th edition of The European recommendations for the management of major
bleeding and coagulopathy following trauma leaves room for various coagulation factor …

Abstract Purpose of Review Coagulopathy is a complex pathological condition manifested
through the insufficient or excessive tendency to form blood thrombi, which can be caused …

Owing to the simultaneous increase in the risk of thrombosis and bleeding in critically ill
patients, point-of-care-available diagnostic tests to guide parenteral anticoagulation are …

Convalescent plasma is used to treat COVID-19. There are theoretical concerns about the
impact of pro-coagulant factors in convalescent plasma on the coagulation cascade …

Background Optimal management of severe trauma patients with active hemorrhage relies
on adequate initial resuscitation. Early administration of coagulation factors improves post …