Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …

Immune checkpoint inhibitors (ICIs) have revolutionized our approach to cancer treatment in
the past decade. While monoclonal antibodies to CTLA‐4 and PD‐1/PD‐L1 have produced …

Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is an inhibitory receptor belonging to
the CD28 immunoglobulin subfamily, expressed primarily by T-cells. Its ligands, CD80 and …

The adaptive immune system is modulated by an important subset of CD4+ T lymphocytes
called Treg cells that function in maintaining immune homeostasis by preventing excessive …

Over the past decade, autophagy has emerged as a critical regulatory mechanism of the
immune system through critically controlling various aspects of T cell biology and …

The past few years have witnessed vast clinical accomplishments of immune checkpoint
blockades (ICB), which block the regulatory receptor expressed on immune cells or tumor …

CD27 is a costimulatory molecule that provides a complementary target to the PD-1/PD-L1
checkpoint axis on T cells. Combining a CD27 agonist antibody with PD-1/PD-L1 blockade …

Agonism of members of the tumor necrosis factor receptor superfamily (TNFRSF) with
monoclonal antibodies is of high therapeutic interest due to their role in immune regulation …

Ferritin is a multivalent, self-assembling protein scaffold found in most human cell types, in
addition to being present in invertebrates, higher plants, fungi, and bacteria, that offers an …

With the progress of immunotherapy in cancer, oncolytic viruses (OVs) have attracted more
and more attention during the past decade. Due to their cancer-selective and immunogenic …