Anti-synthetase syndrome (ASSD) is an autoimmune disease characterized by the presence
of autoantibodies targeting one of several aminoacyl t-RNA synthetases (aaRSs) along with …

Autoantibodies are a hallmark in the diagnosis of many systemic autoimmune rheumatic
diseases (SARD) including idiopathic inflammatory myopathies (IIM). Based on their …

The discovery of novel autoantibodies related to idiopathic inflammatory myopathies
(collectively referred to as myositis) has not only advanced our understanding of the clinical …

Background The skeletal muscle mass is the largest organ in the healthy body, comprising
30–40% of the body weight of an adult man. It confers protection from trauma, locomotion …

Objective To determine if distinct muscle pathologic features exist in scleroderma subjects
with weakness. Methods This retrospective study included weak scleroderma subjects with …

A significant number of patients with autoimmune myopathy have a predominantly
necrotizing muscle biopsy with minimal lymphocytic infiltration. This biopsy finding occurs in …

High prevalence of necrotising myopathy pattern in muscle biopsies of patients with anti-Jo-1
antisynthetase syndrome Page 1 Clinical and Experimental Rheumatology 2022 Clinical and …

Anti-HMGCR antibodies represent a characteristic serological feature of statin-exposed and
statin-unexposed patients with immune-mediated necrotizing myopathy (IMNM). We …

Auto-antibodies against aminoacyl-tRNA-synthetases (anti-ARS Abs) represent the hallmark
of the anti-synthetase syndrome that is defined as the clinical association of fever …

Background Immune-mediated necrotizing myopathy (IMNM) is a relatively new proposed
category of idiopathic inflammatory myopathies (IIMs), characterized by the presence of …