Pathogenicity and virulence of Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …
Tuberculosis and HIV co-infection
A Pawlowski, M Jansson, M Sköld… - PLoS …, 2012 - journals.plos.org
Tuberculosis (TB) and HIV co-infections place an immense burden on health care systems
and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most …
and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most …
Natural selection and infectious disease in human populations
EK Karlsson, DP Kwiatkowski, PC Sabeti - Nature Reviews Genetics, 2014 - nature.com
The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …
genetic variation in modern populations, and this has important implications for the growing …
Co‐evolution of Mycobacterium tuberculosis and Homo sapiens
The causative agent of human tuberculosis (TB), M ycobacterium tuberculosis, is an obligate
pathogen that evolved to exclusively persist in human populations. For M. tuberculosis to …
pathogen that evolved to exclusively persist in human populations. For M. tuberculosis to …
Innate immune gene polymorphisms in tuberculosis
Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single
infectious agent. Recent studies targeting candidate genes and “case-control” association …
infectious agent. Recent studies targeting candidate genes and “case-control” association …
Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration
Human genetic factors predispose to tuberculosis (TB). We studied 7.6 million genetic
variants in 5,530 people with pulmonary TB and in 5,607 healthy controls. In the combined …
variants in 5,530 people with pulmonary TB and in 5,607 healthy controls. In the combined …
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population
The worldwide burden of tuberculosis (TB) remains an enormous problem, and is
particularly severe in the admixed South African Coloured (SAC) population residing in the …
particularly severe in the admixed South African Coloured (SAC) population residing in the …
The role of iron in the immune response to bacterial infection
BJ Cherayil - Immunologic research, 2011 - Springer
My laboratory has been interested for some time in the influence of iron, a nutrient that is
essential for both microbial pathogens and their mammalian hosts, on the course of …
essential for both microbial pathogens and their mammalian hosts, on the course of …
Common variants at 11p13 are associated with susceptibility to tuberculosis
After imputation of data from the 1000 Genomes Project into a genome-wide dataset of
Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on …
Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on …
Crohn's disease and the mycobacterioses: a quarter century later. Causation or simple association?
RJ Chiodini, WM Chamberlin, J Sarosiek… - Critical reviews in …, 2012 - Taylor & Francis
It has been more than 25 years since Mycobacterium paratuberculosis was first proposed as
an etiologic agent in Crohn's disease based on the isolation of this organism from several …
an etiologic agent in Crohn's disease based on the isolation of this organism from several …