Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor
for end-stage liver diseases with no available therapies. Dysregulated immune responses …

Type I Interferons (IFNs) are hallmark cytokines produced in immune responses to all
classes of pathogens. Type I IFNs can influence dendritic cell (DC) activation, maturation …

B cells are activated by two temporally distinct signals, the first provided by the binding of
antigen to the B cell antigen receptor (BCR), and the second provided by helper T cells …

The humoral immune response and antibody-mediated functions of B cells during viral
infections are well described. However, we have limited understanding of antibody …

Inflammation has accompanied human beings since the emergence of wounds and
infections. In the past decades, numerous efforts have been undertaken to explore the …

During antigen-driven responses, B cells can differentiate at extra-follicular (EF) sites or
initiate germinal centers (GCs) in processes that involve interactions with T cells. Here, we …

Key events in T cell–dependent antibody responses, including affinity maturation, are
dependent on the B cell's presentation of antigen to helper T cells at critical checkpoints in …

The current concepts for development of autoreactive B cells in SLE (systemic lupus
erythematosus) focus on extrinsic stimuli and factors that provoke B cells into tolerance loss …

Highlights•B cell progenitors are metabolically active during expansion and silent during Ig
recombination.•Upon antigenic stimuli, naïve B cells rapidly increase both glycolysis and …

Abstract Background Strategies to prevent Mycobacterium tuberculosis (Mtb) infection are
urgently required. In this study, we aimed to identify correlates of protection against Mtb …