Aberrant patterns of brain functional connectivity in the default mode network (DMN) have
been observed across different classes of substance use disorder (SUD) and are associated …

This paper presents a novel neurobiological model of theory of mind (ToM) that incorporates
both neuroanatomical and neurochemical levels of specificity. Within this model, cortical and …

Background Duplications and deletions in the human genome can cause disease or
predispose persons to disease. Advances in technologies to detect these changes allow for …

This review summarizes our current understanding of catechol-o-methyltransferase (COMT)
and how it relates to brain function and schizophrenia. We begin by considering the COMT …

BackgroundNeurocognitive dysfunction in schizophrenia (SZ), bipolar (BD) and related
disorders represents a core feature of these illnesses, possibly a marker of underlying …

Chromosome 22q11. 2 deletion syndrome (22q11. 2DS), a neurogenetic condition, is the
most common microdeletion syndrome affecting 1 in 2,000–4,000 live births and involving …

Context CatecholO-methyltransferase (COMT), the major enzyme determining cortical
dopamine flux, has a common functional polymorphism (val 158 met) that affects prefrontal …

Abstract Chromosome 22q11. 21 contains a cluster of low-copy repeats (LCRs), referred to
as LCR22A-H, that mediate meiotic non-allelic homologous recombination, resulting in …

The important contribution of genetic factors to the development of cognition and intelligence
is widely acknowledged, but identification of these genes has proven to be difficult. Given a …

Chromosomal abnormalities, including microdeletions and microduplications, have long
been associated with abnormal developmental outcomes. Early discoveries relied on a …