The high density structure of cartilage matrix negative charge seriously hinders the
penetration and enrichment of drugs/genes into cartilage tissue. In this study …

Background/Objectives: Current promising treatments for many diseases are based on the
use of therapeutic nucleic acids, including DNA. However, the list of nanocarriers is limited …

Conventional small molecular chemical drugs always have challenging limitations in cancer
therapy due to their high systemic toxicity and low therapeutic efficacy. Nanotechnology has …

Nanoplatforms with amplified passive tumor targeting and enhanced protein resistance can
evade unnecessary uptake by the reticuloendothelial system and achieve high tumor …

Combined chemo/gene therapy of cancer through different action mechanisms has been
emerging to enhance the therapeutic efficacy towards cancer, and still remains a …

Development of nanomedicines for effective therapy of acute lung injury (ALI), a common
critical respiratory failure syndrome, remains to be challenging. We report here a unique …

The development of nonviral dendritic polymers with a simple molecular backbone and
great gene delivery efficiency to effectively tackle cancer remains a great challenge …

Cancer is one of the most common diseases in developed countries. Recently, gene therapy
has emerged as a promising approach to cancer treatment and has already entered clinical …

Development of nanomedicines that can collaboratively scavenge reactive oxygen species
(ROS) and inhibit inflammatory cytokines, along with osteogenesis promotion, is essential …

Design of multifunctional nanoplatforms combined with ultrasound-targeted microbubble
destruction (UTMD) technology for enhanced tumor accumulation is feasible to solve the …