The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful
blood-borne, endogenous and exogenous substances and maintains the homeostatic …

Vascular disruption is the underlying cause of cerebral hemorrhage, including intracerebral,
subarachnoid and intraventricular hemorrhage. The disease etiology also involves cerebral …

Mast cell activation plays an important role in stress-mediated disease pathogenesis.
Chronic stress cause or exacerbate aging and age-dependent neurodegenerative diseases …

Occludin is a key structural component of the blood–brain barrier (BBB) that has recently
become an important focus of research in BBB damages. Many studies have demonstrated …

Claudin-5 is a tight junction (TJ) protein in the blood-brain barrier (BBB) that has recently
attracted increased attention. Numerous studies have demonstrated that claudin-5 regulates …

Stroke continues to be the third-leading cause of death and disability worldwide. The limited
availability of diagnostic tools approved therapeutics and biomarkers that help monitor …

Background Neuroinflammation often develops in sepsis along with increasing permeability
of the blood-brain barrier (BBB), which leads to septic encephalopathy. The barrier is formed …

Stroke is classified into two main groups depending on its aetiology; ischaemic stroke and
haemorrhagic stroke which successively develop from the occlusion or rupture of an artery …

The blood–brain barrier (BBB) is a cellular and physical barrier with a crucial role in
homeostasis of the brain extracellular environment. It controls the imports of nutrients to the …

Growing evidence has proved that alterations in the gut microbiota have been linked to
neurological disorders including stroke. Structural and functional disruption of the blood …