The myelination of axons has evolved to enable fast and efficient transduction of electrical
signals in the vertebrate nervous system. Acting as an electric insulator, the myelin sheath is …

Schizophrenia and bipolar disorder are disabling psychiatric disorders with a worldwide
prevalence of approximately 1%. Both disorders present chronic and deteriorating …

To enable rapid propagation of action potentials, axons are ensheathed by myelin, a
multilayered insulating membrane formed by oligodendrocytes. Most of the myelin is …

The TREM2–DAP12 receptor complex sustains microglia functions. Heterozygous
hypofunctional TREM2 variants impair microglia, accelerating late-onset Alzheimer's …

Myelin is essential for rapid nerve signaling and is increasingly found to play important roles
in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as …

Myelin membranes are dominated by lipids while the complexity of their protein composition
has long been considered to be low. However, numerous additional myelin proteins have …

Myelination of axons provides the structural basis for rapid saltatory impulse propagation
along vertebrate fiber tracts, a well-established neurophysiological concept. However …

Human myelin disorders are commonly studied in mouse models. Since both clades
evolutionarily diverged approximately 85 million years ago, it is critical to know to what …

Proteome and transcriptome analyses aim at comprehending the molecular profiles of the
brain, its cell-types and subcellular compartments including myelin. Despite the relevance of …

Traumatic brain injury (TBI) often damages axons in white matter tracts and causes corpus
callosum (CC) atrophy in chronic TBI patients. Injured axons encounter irreversible damage …