For decades, it was commonly accepted that the brain is secluded from peripheral immune
activity and is self-sufficient for its maintenance and repair. This simplistic perception was …

Increasing evidence corroborates the fundamental role of neuroinflammation in the
development of epilepsy. Proinflammatory cytokines (PICs) are crucial contributors to the …

After ischemic stroke, the integrity of the blood-brain barrier is compromised. Peripheral
immune cells, including neutrophils, T cells, B cells, dendritic cells, and macrophages …

Neuroinflammation is a major contributor to disease progression in Alzheimer's disease
(AD) and is characterized by the activity of brain resident glial cells, in particular microglia …

Radiation-induced late brain injury consisting of vascular abnormalities, demyelination,
white matter necrosis, and cognitive impairment has been described in patients subjected to …

Microglia are the resident innate immune cells of the central nervous system (CNS)
parenchyma. To determine the impact of microglia on disease development and progression …

Abstract Alpha-synuclein (α-syn) has been suggested to have many functions including,
vesicle transport in neurons, transcriptional regulator, modulator of immune cell maturation …

Background: The blood–brain barrier acts as a highly regulated interface; its dysfunction
may exacerbate, and perhaps initiate, neurological and neuropsychiatric disorders …

2262 Stroke September 2018 involving severe endothelial damage, vessel rupture, and
microbleeds or hemorrhagic transformation, are expected to facilitate the presence of …

Glioblastoma (GBM) is the most common and fatal primary central nervous system
malignancy in adults with a median survival of less than 15 months. Surgery, radiation, and …