The roles of extracellular vesicles in the immune system

EI Buzas - Nature Reviews Immunology, 2023 - nature.com
The twenty-first century has witnessed major developments in the field of extracellular
vesicle (EV) research, including significant steps towards defining standard criteria for the …

The principles of directed cell migration

S SenGupta, CA Parent, JE Bear - Nature Reviews Molecular Cell …, 2021 - nature.com
Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

Extracellular vesicles: mediators of intercellular communication in tissue injury and disease

G Berumen Sánchez, KE Bunn, HH Pua… - Cell Communication and …, 2021 - Springer
Intercellular communication is a critical process that ensures cooperation between distinct
cell types and maintains homeostasis. EVs, which were initially described as cellular debris …

Exosomes: biogenesis, biologic function and clinical potential

Y Zhang, Y Liu, H Liu, WH Tang - Cell & bioscience, 2019 - Springer
Exosomes are nano-sized biovesicles released into surrounding body fluids upon fusion of
multivesicular bodies and the plasma membrane. They were shown to carry cell-specific …

Re-engineering extracellular vesicles as smart nanoscale therapeutics

JPK Armstrong, MN Holme, MM Stevens - ACS nano, 2017 - ACS Publications
In the past decade, extracellular vesicles (EVs) have emerged as a key cell-free strategy for
the treatment of a range of pathologies, including cancer, myocardial infarction, and …

Regulation of immune responses by extracellular vesicles

PD Robbins, AE Morelli - Nature Reviews Immunology, 2014 - nature.com
Extracellular vesicles, including exosomes, are small membrane vesicles derived from
multivesicular bodies or from the plasma membrane. Most, if not all, cell types release …

Dendritic cell–derived exosomes for cancer therapy

JM Pitt, F André, S Amigorena, JC Soria… - The Journal of …, 2016 - Am Soc Clin Investig
DC-derived exosomes (Dex) are nanometer-sized membrane vesicles that are secreted by
the sentinel antigen-presenting cells of the immune system: DCs. Like DCs, the molecular …

Biological properties of extracellular vesicles and their physiological functions

M Yáñez-Mó, PRM Siljander, Z Andreu… - Journal of …, 2015 - Taylor & Francis
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …

Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials

YF Chen, F Luh, YS Ho, Y Yen - Journal of Biomedical Science, 2024 - Springer
Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids,
proteins, lipids, and metabolites. They mediate the exchange of substances between cells …

The crosstalk: Exosomes and lipid metabolism

W Wang, N Zhu, T Yan, YN Shi, J Chen… - Cell Communication and …, 2020 - Springer
Exosomes have been considered as novel and potent vehicles of intercellular
communication, instead of “cell dust”. Exosomes are consistent with anucleate cells, and …