Simple Summary Chronic myeloid leukemia (CML) is a myeloproliferative neoplasia
associated with a molecular alteration, the fusion gene BCR-ABL1, that encodes the tyrosine …

The treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKIs) has
been a model for cancer therapy development. Though most patients with CML have a …

Epithelial growth factor receptor (EGFR) is a cell surface transmembrane receptor that
mediates the tyrosine signaling pathway to carry the extracellular messages inside the cell …

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor outcome and
lacks of approved targeted therapy. Overexpression of epidermal growth factor receptor …

Acute myeloid leukemia (AML) has a high rate of treatment failure due to increased
prevalence of therapy resistance. Mesenchymal stem cells (MSCs) in the leukemia …

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm initiated by the presence
of the fusion gene BCR:: ABL1. The development of tyrosine kinase inhibitors (TKIs) highly …

Abstract Purpose of Review Tyrosine kinase inhibitors (TKIs) are very successful for the
treatment of chronic myeloid leukaemia (CML) but are not curative in most patients due to …

Cancer is recognized as a preeminent factor of the world's mortality. Although various
modalities have been designed to cure this life-threatening ailment, a significant impediment …

To orchestrate collective polarization across tissues, planar cell polarity (PCP) proteins
localize asymmetrically to cell junctions, a conserved feature of PCP that requires the …

Purpose Chronic myeloid leukemia (CML) is a hematological malignancy characterized by
the presence of BCR-ABL protein. Imatinib (IMA) is considered as the first line therapy in …