AML-associated mutations in DNA methyltransferase DNMT3A
DA Khrabrova, MG Yakubovskaya, ES Gromova - Biochemistry (Moscow), 2021 - Springer
In mammals, DNA methylation is an essential epigenetic modification necessary for the
maintenance of genome stability, regulation of gene expression, and other processes …
maintenance of genome stability, regulation of gene expression, and other processes …
Dimeric bisbenzimidazoles inhibit the DNA methylation catalyzed by the murine Dnmt3a catalytic domain
NA Cherepanova, AA Ivanov, DV Maltseva… - Journal of Enzyme …, 2011 - Taylor & Francis
When located in the DNA minor groove, dimeric bisbenzimidazoles DB (n) effectively
inhibited in vitro the Dnmt3a catalytic domain (IC50 5–77 μM). The lowest IC50 value was …
inhibited in vitro the Dnmt3a catalytic domain (IC50 5–77 μM). The lowest IC50 value was …
The effect of antitumor antibiotic olivomycin A and its new semi-synthetic derivative olivamide on the activity of murine DNA methyltransferase Dnmt3a
AV Sergeev, AN Tevyashova, AP Vorobyov… - Biochemistry …, 2019 - Springer
Olivomycin A is a highly active antitumor drug that belongs to the family of aureolic acid
antibiotics. The antitumor effect of olivomycin A is related to its ability to bind to the DNA …
antibiotics. The antitumor effect of olivomycin A is related to its ability to bind to the DNA …
Dimeric bisbenzimidazoles: Cytotoxicity and effects on DNA methylation in normal and cancer human cells
MV Darii, AR Rakhimova, VN Tashlitsky, SV Kostyuk… - Molecular Biology, 2013 - Springer
Cancer cells are characterized by hypermethylation of the promoter regions of tumor
suppressor genes. DNA methyltransferase inhibitors reactivate the genes, pointing to DNA …
suppressor genes. DNA methyltransferase inhibitors reactivate the genes, pointing to DNA …
Symmetric dimeric bisbenzimidazoles DBP(n) reduce methylation of RARB and PTEN while significantly increase methylation of rRNA genes in MCF-7 cancer cells
SV Kostyuk, MA Kvasha, DA Khrabrova, OV Kirsanova… - Plos one, 2018 - journals.plos.org
Background Hypermethylation is observed in the promoter regions of suppressor genes in
the tumor cancer cells. Reactivation of these genes by demethylation of their promoters is a …
the tumor cancer cells. Reactivation of these genes by demethylation of their promoters is a …
[HTML][HTML] EPIGENETIC CHANGES IN POST-TRAUMATIC STRESS DISORDER: POSSIBILITIES AND LIMITATIONS OF EPIGENETIC THERAPY
IO Suchkova, EL Patkin, SG Tsikunov… - Medical academic …, 2024 - journals.eco-vector.com
The review describes epigenetic mechanisms that may contribute to individual differences in
resistance and risk of developing post-traumatic stress disorder. The review provides data …
resistance and risk of developing post-traumatic stress disorder. The review provides data …
[PDF][PDF] Einfachheit biochemischer Komplexität–ein Widerspruch
S Müller - Sitzungsberichte der Leibniz-Sozietät, 2010 - leibnizsozietaet.de
In der Literatur, in verschiedenen Lexika und online-Nachschlagewerken finden sich eine
Reihe von Definitionen für „Einfachheit “, die sich aber alle darüber einig sind, dass …
Reihe von Definitionen für „Einfachheit “, die sich aber alle darüber einig sind, dass …
Analysen epigenetischer Marker aus Liquid Biopsies: Informationen von jenseits des Genoms
O Ammerpohl, S Scheufele, R Siebert - medizinische genetik, 2016 - degruyter.com
Zusammenfassung Die Analyse epigenetischer Marker aus Liquid Biopsies erlaubt
Einblicke in physiologische und pathologische Prozesse im Körper einer Person, die über …
Einblicke in physiologische und pathologische Prozesse im Körper einer Person, die über …
Inhibition of murine DNA methyltransferase Dnmt3a by DNA duplexes containing pyrimidine-2(1H)-one
NA Cherepanova, AL Zhuze, ES Gromova - Biochemistry (Moscow), 2010 - Springer
Here we studied the inhibition of the catalytic domain of Dnmt3a methyltransferase (Dnmt3a-
CD) by DNA duplexes containing the mechanism-based inhibitor pyrimidine-2 (1 H)-one (P) …
CD) by DNA duplexes containing the mechanism-based inhibitor pyrimidine-2 (1 H)-one (P) …
Мутации в ДНК-метилтрансферазе DNMT3A при остром миелоидном лейкозе
ДА Храброва, МГ Якубовская, ЕС Громова - Биохимия, 2021 - elibrary.ru
У млекопитающих метилирование ДНК является важной эпигенетической
модификацией, необходимой для регуляции экспрессии генов, поддержания …
модификацией, необходимой для регуляции экспрессии генов, поддержания …