The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

With the discovery of cisplatin, a vast area of applications of metallodrugs in cancer
treatment was opened but due to the side effects caused by the cisplatin complexes …

Ruthenium-based complexes have emerged as promising antitumor and antimetastatic
agents during the past decades. However, the limited understanding of the antimetastatic …

The triple-negative breast cancer subtype (TNBC) is highly aggressive and metastatic and
corresponds to 15–20% of diagnosed cases. TNBC treatment is hampered, because these …

Biological properties of the arene–ruthenium complexes have attracted substantial current
interest. Their activity is appreciably defined and controlled by the arene moieties, organic …

Arene Ru (II) complexes have long been extensively studied as potential inhibitors against
the proliferation of tumor cells, but their behavior against the migration and invasion of tumor …

Application of mild hyperthermia can increase the cytotoxicity of anticancer drugs in tumour
cells. In this report, we describe low molecular weight thermoactive ruthenium-based drugs …

The four novel complexes [{cis-PtCl (NH 3) 2 (μ-4, 4′-bipyridyl) ZnCl (terpy)}](ClO 4) 2
(C1),[{trans-PtCl (NH 3) 2 (μ-4, 4′-bipyridyl) ZnCl (terpy)}](ClO 4) 2 (C2),[{cis-PtCl (NH 3) 2 …

Two p-cymenerutheniumchlorido complexes with thiourea derivative of 7-chloroquinoline
(C1) and pyridine-3-imidazole (C2) were synthesized starting from [(η6-p-cymene) RuCl2] 2 …

Small-molecule inhibitors of poly (ADP-ribose) polymerase-1 (PARP-1) have currently
drawn much attention as promising chemotherapeutic drug candidates, and there is a need …