Circulating tumor cells (CTCs) shed from primary and metastatic cancers are admixed with
blood components and are thus rare, making their isolation and characterization a major …

Without epithelial–mesenchymal transitions, in which polarized epithelial cells are converted
into motile cells, multicellular organisms would be incapable of getting past the blastula …

Circulating tumor cells (CTC) in blood are promising new biomarkers potentially useful for
prognostic prediction and monitoring of therapies in patients with solid tumors including …

Cancer cells possess a broad spectrum of migration and invasion mechanisms. These
include both individual and collective cell-migration strategies. Cancer therapeutics that are …

Despite considerable advancements that shattered previously held dogmas about the
metastatic cascade, the evolution of therapies to treat metastatic disease has not kept up. In …

Despite recent progress in gene-expression profiling studies, the biology underlying the
various patterns of metastasis that are observed in different tumour types remains unclear …

Epithelial–mesenchymal transition (EMT) is a key step during embryogenesis. Accumulating
evidence suggests a critical role in cancer progression, through which tissue epithelial …

Tumor cells can evade chemotherapy by acquiring resistance to apoptosis. We investigated
the molecular mechanism whereby malignant and nonmalignant mammary epithelial cells …

In contrast to the aberrant control of proliferation, apoptosis, angiogenesis and lifespan, the
cellular mechanisms that cause local invasion and metastasis of tumour cells are still poorly …

Despite increased focus on the clinical relevance of dormant metastatic disease, our
understanding of dormant niches, mechanisms underlying emergence from dormancy, and …