Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …

This Perspective recapitulates recent developments of carbon dioxide utilization in carbon–
carbon bond formation reactions, with an intention of paving a way toward sustainable CO2 …

Cu/Ir dual catalysis has been developed for the stereodivergent α-allylation of aldimine
esters. The method enables the preparation of a series of nonproteinogenic α-amino acids …

Structural analysis of modern pharmaceutical practices allows for the identification of two
rapidly growing trends: the introduction of tailor‐made amino acids and the exploitation of …

Transition‐metal catalyzed enantioconvergent cross‐coupling of tertiary alkyl halides with
ammonia offers a rapid avenue to chiral unnatural α, α‐disubstituted amino acids. However …

An unprecedented enantioselective allylic alkylation of readily available aldimine esters has
been developed, and is catalyzed by a synergistic Cu/Pd catalyst system. This strategy …

A copper-catalyzed asymmetric synthesis of unnatural β-germyl α-amino acids is developed.
This process undergoes an intermolecular enantioselective hydrogermylation of …

Aliphatic primary amines are a class of chemical feedstock essential to the synthesis of
higher-order nitrogen-containing molecules, commonly found in biologically active …

Classical amination methods involve the reaction of a nitrogen nucleophile with an
electrophilic carbon center; however, in recent years, umpoled strategies have gained …

Tailor-made AAs are indispensable components of modern medicinal chemistry and are
becoming increasingly prominent in new drugs. In fact, about 30% of small-molecule …