The quest for new approaches in myocarditis and inflammatory cardiomyopathy
S Heymans, U Eriksson, J Lehtonen… - Journal of the American …, 2016 - jacc.org
Myocarditis is a diverse group of heart-specific immune processes classified by clinical and
histopathological manifestations. Up to 40% of dilated cardiomyopathy is associated with …
histopathological manifestations. Up to 40% of dilated cardiomyopathy is associated with …
Acute Chagas disease: new global challenges for an old neglected disease
Chagas disease is caused by infection with the protozoan Trypanosoma cruzi, and although
over 100 years have passed since the discovery of Chagas disease, it still presents an …
over 100 years have passed since the discovery of Chagas disease, it still presents an …
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue‐specific parasite dynamics and heart disease in the absence of locally persistent …
Chronic T rypanosoma cruzi infections lead to cardiomyopathy in 20–30% of cases. A
causal link between cardiac infection and pathology has been difficult to establish because …
causal link between cardiac infection and pathology has been difficult to establish because …
CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production
Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in
several conditions. However, we have little understanding of the mechanisms by which …
several conditions. However, we have little understanding of the mechanisms by which …
Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis
Disease progression in response to infection can be strongly influenced by both pathogen
burden and infection-induced immunopathology. While current therapeutics focus on …
burden and infection-induced immunopathology. While current therapeutics focus on …
[HTML][HTML] Heart inflammation: immune cell roles and roads to the heart
FJ Carrillo-Salinas, N Ngwenyama… - The American journal of …, 2019 - Elsevier
Heart failure (HF) has been traditionally viewed as a disease of the cardiac muscle
associated with systemic inflammation. Burgeoning evidence implicates immune effector …
associated with systemic inflammation. Burgeoning evidence implicates immune effector …
Variable gene expression and parasite load predict treatment outcome in cutaneous leishmaniasis
Patients infected with Leishmania braziliensis develop chronic lesions that often fail to
respond to treatment with antiparasite drugs. To determine whether genes whose …
respond to treatment with antiparasite drugs. To determine whether genes whose …
[HTML][HTML] TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease
RR Ferreira, R da Silva Abreu… - PLoS neglected …, 2019 - journals.plos.org
TGF-β involvement in Chagas disease cardiomyopathy has been clearly demonstrated. The
TGF-β signaling pathway is activated in the cardiac tissue of chronic phase patients and is …
TGF-β signaling pathway is activated in the cardiac tissue of chronic phase patients and is …
Protective and Pathological Functions of CD8+ T Cells in Leishmania braziliensis Infection
TM Cardoso, Á Machado, DL Costa… - Infection and …, 2015 - Am Soc Microbiol
Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by a
strong Th1 response that leads to skin lesion development. In areas where L. braziliensis …
strong Th1 response that leads to skin lesion development. In areas where L. braziliensis …
CCL3/macrophage inflammatory protein-1α is dually involved in parasite persistence and induction of a TNF-and IFNγ-enriched inflammatory milieu in Trypanosoma …
CCL3, a member of the CC-chemokine family, has been associated with macrophage
recruitment to heart tissue and parasite control in the acute infection of mouse with …
recruitment to heart tissue and parasite control in the acute infection of mouse with …