Over the years, my colleagues and I have come to realise that the likelihood of
pharmaceutical drugs being able to diffuse through whatever unhindered phospholipid …

G-protein coupled receptors (GPCRs), one of the largest superfamilies of cell-surface
receptors, are heptahelical integral membrane proteins that play critical roles in virtually …

Within the last 2 decades, severe acute respiratory syndrome coronaviruses 1 and 2 (SARS-
CoV-1 and SARS-CoV-2) have caused two major outbreaks; yet, for reasons not fully …

The protein–ligand binding affinity quantifies the binding strength between a protein and its
ligand. Computer modeling and simulations can be used to estimate the binding affinity or …

By undergoing conformational changes, active membrane transporters alternate between an
inward-facing (IF) and an outward-facing (OF) state to transport their substrates across …

Proton-coupled peptide transporters (POTs) are crucial for the uptake of di-and tripeptides
as well as drug and prodrug molecules in prokaryotes and eukaryotic cells. We illustrate …

Members of the parvalbumin (PV) family of calcium (Ca2+) binding proteins (CBPs) share a
relatively high level of sequence similarity. However, their Ca2+ affinities and selectivities …

Proton‐dependent oligopeptide transporters (POT s) are important for the uptake of di‐
/tripeptides in many organisms and for drug transport in humans. The binding mode of …

YidC is a membrane protein that facilitates the insertion of newly synthesized proteins
across the membrane. YidC inserts protein into the membrane bilayer via the SecYEG …

Mechanosensitive channel of large conductance (MscL) detects and responds to changes in
the pressure profile of cellular membranes and transduces the mechanical energy into …