The free radical nitric oxide (· NO) is a key mediator in different physiological processes such
as vasodilation, neurotransmission, inflammation, and cellular immune responses, and thus …

The cellular stress response (CSR) is pervasive to all domains of life. It has shaped the
interaction between organisms and their environment since the origin of the first cell …

Global climate change has a significant effect on extreme environments and a profound
influence on species survival. However, little is known of the genome-wide pattern of …

Background: Prenatal exposure to air pollution is considered to be associated with adverse
effects on child health. This may partly be mediated by mechanisms related to DNA …

Triterpenoids are natural compounds synthesized by plants through cyclization of squalene,
known for their weak anti-inflammatory activity. 2-cyano-3, 12-dioxooleana-1, 9 (11)-dien-28 …

To ensure correct function, mitochondria have developed several mechanisms of protein
quality control (QC). Protein homeostasis highly relies on chaperones and proteases to …

Metabolic syndrome (MetS) is a precursor to the major health diseases associated with high
mortality in industrialized countries: cardiovascular disease and diabetes. An important …

The increased prevalence of age-related comorbidities and mortality is worrisome in ageing
HIV-infected patients. Here, we aim to analyse the different ageing mechanisms with regard …

Lon protease is a nuclear-encoded, mitochondrial ATP-dependent protease highly
conserved throughout the evolution, crucial for the maintenance of mitochondrial …

Initially discovered as a protease responsible for degradation of misfolded or damaged
proteins, the mitochondrial Lon protease (Lonp1) turned out to be a multifaceted enzyme …