Gene therapy for neurological disorders has attracted significant interest as a way to reverse
or stop various disease pathologies. Typical gene therapies involving the central and …

The delivery of therapeutic nucleic acids to neurons has the potential to treat neurological
disease and spinal cord injury. While select viral vectors have shown promise as gene …

Nucleic acids, including plasmid DNA (pDNA) and small interfering RNA (siRNA), are
potential therapeutic macromolecules that have been widely explored for the treatment or …

The progressive degeneration of the dopamine neurons of the pars compacta of substantia
nigra and the consequent loss of the dopamine innervation of the striatum leads to the …

Many viral and nonviral systems have been developed to aid delivery of biologically active
molecules into cells. Among these, cell‐penetrating peptides (CPPs) have received …

Background The anti-inflammatory effect of the cerebral dopamine neurotrophic factor
(CDNF) was shown recently in primary glial cell cultures, yet such effect remains unknown …

Abstract Background The neurotrophin Brain-Derived Neurotrophic Factor (BDNF)
influences nigral dopaminergic neurons via autocrine and paracrine mechanisms. The …

Brain tumor patients face a poor prognosis despite significant advances in tumor imaging,
neurosurgery and radiation therapy. Potent chemotherapeutic drugs fail when used to treat …

Cell-penetrating peptides (CPP) have become a widely used tool for efficient cargo delivery
into cells. However, one limiting fact is their uptake by endocytosis causing the enclosure of …

Most brain diseases such as tumors and neurodegenerative diseases are devastating for
patients with high morbidity and mortality. Gene therapy is a promising strategy for the …