Aging of biological systems occurs in spite of numerous complex pathways of maintenance,
repair and defense. There are no gerontogenes which have the specific evolutionary …

Individuals of the same age differ greatly with respect to their health status and life span. We
have suggested that the health status of individuals can be represented by the number of …

We previously quantified frailty in aged mice with frailty index (FI) that used specialized
equipment to measure health parameters. Here we developed a simplified, noninvasive …

Biological aging measures have been proposed as proxies for extension of healthy life span
in trials of geroprotective therapies that aim to slow aging. Several methods to measure …

The health of individuals is highly heterogeneous, as is the rate at which they age. To
account for such heterogeneity, we have suggested that an individual's health status can be …

Increasing life expectancy has been interpreted as improving health of a population.
However, mortality is not always a reliable proxy for the pace of aging and could instead …

Background The frailty index (FI) is used to measure the health status of ageing individuals.
An FI is constructed as the proportion of deficits present in an individual out of the total …

Objectives to investigate how frailty and mobility impairment affect recovery of balance and
mobility in acutely ill older patients. Design secondary analysis of cohort study. Setting …

Recently suggested novel implementation of the statistical distance measure (DM) for
evaluating “physiological dysregulation”(PD) in aging individuals (based on measuring …

The TOMM40‐APOE variants are known for their strong, antagonistic associations with
Alzheimer's disease and body weight. While a stronger role of the APOE than TOMM40 …