Cancer is a growing global burden; there were an estimated 18 million new cancer
diagnoses worldwide in 2020. Excisional surgery remains one of the main treatments for …

Simple Summary Removal of the primary tumor is the best treatment for solid tumor disease.
However, perioperative factors such as surgical stress, pain, or anemia disrupt the innate …

Head and neck squamous cell carcinomas (HNSCCs) are cancers that arise in the mucosa
of the upper aerodigestive tract. The five-year patient survival rate is~ 50%. Treatment …

Head and neck squamous cell carcinomas (HNSCCs) have high mortality and significant
treatment-related morbidity. It is vital to discover effective, minimally invasive therapies that …

The major goal of translational research is to evaluate the efficacy and effectiveness of
treatments and interventions that have emerged from exhaustive preclinical evidence. In …

The development of therapies that can suppress invasion and prevent metastasis,'anti-
metastatic drugs', is an important area of unmet therapeutic need. The new results of a …

The use of low-dose local anesthetics (LAs) has significantly transformed patient care by
providing rapid and effective relief of pain and other clinical conditions while minimizing …

Solid tumours have abnormally high intracellular [Na+]. The activity of various Na+ channels
may underlie this Na+ accumulation. Voltage-gated Na+ channels (VGSCs) have been …

The disparity in access to and quality of surgical cancer care between high and low resource
settings impacts immediate and long‐term oncological outcomes. With cancer incidence and …

Since its development in 1943, lidocaine has been one of the most commonly used local
anesthesia agents for surgical procedures. Lidocaine alters neuronal signal transmission by …