The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the
treatment of severe infections in humans caused by MDR Gram-positive bacteria. They bind …

Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common
commensals and major opportunistic human pathogens. In recent decades, these bacteria …

The ribosome is a major target for clinically used antibiotics, but multidrug resistant
pathogenic bacteria are making our current arsenal of antimicrobials obsolete. Here we …

Genome-encoded antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F
subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The …

Ribosome serves as a universal molecular machine capable of synthesis of all the proteins
in a cell. Small-molecule inhibitors, such as ribosome-targeting antibiotics, can compromise …

Having multiple rounds of translation of the same mRNA creates dynamic complexities
along with opportunities for regulation related to ribosome pausing and stalling at specific …

HflX is a ubiquitous bacterial GTPase that splits and recycles stressed ribosomes. In addition
to HflX, Listeria monocytogenes contains a second HflX homolog, HflXr. Unlike HflX, HflXr …

Efficiency of protein synthesis on the ribosome is strongly affected by the amino acid
composition of the assembled amino acid chain. Challenging sequences include proline …

Organisms possess a wide variety of proteins with diverse amino acid sequences, and their
synthesis relies on the ribosome. Empirical observations have led to the misconception that …

The rise of multidrug-resistant bacterial infections is a cause of global concern. There is an
urgent need to both revitalize antibacterial agents that are ineffective due to resistance while …