Transcriptional control of energy metabolism by nuclear receptors
C Scholtes, V Giguère - Nature reviews Molecular cell biology, 2022 - nature.com
Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …
respond to physiological cues to generate the energy required for anabolic pathways …
Mechanistic aspects of carotenoid health benefits–where are we now?
Dietary intake and tissue levels of carotenoids have been associated with a reduced risk of
several chronic diseases, including cardiovascular diseases, type 2 diabetes, obesity, brain …
several chronic diseases, including cardiovascular diseases, type 2 diabetes, obesity, brain …
Evolutionary selection and constraint on human knee chondrocyte regulation impacts osteoarthritis risk
During human evolution, the knee adapted to the biomechanical demands of bipedalism by
altering chondrocyte developmental programs. This adaptive process was likely not without …
altering chondrocyte developmental programs. This adaptive process was likely not without …
Gender differences in bile acids and microbiota in relationship with gender dissimilarity in steatosis induced by diet and FXR inactivation
This study aims to uncover how specific bacteria and bile acids (BAs) contribute to steatosis
induced by diet and farnesoid X receptor (FXR) deficiency in both genders. A control diet …
induced by diet and farnesoid X receptor (FXR) deficiency in both genders. A control diet …
[HTML][HTML] Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet–induced systemic inflammation, microglial activation, and reduced …
The goal of this study was to identify the intrinsic links that explain the effect of a Western diet
(WD) on cognitive dysfunction. Specific pathogen-free, wild-type mice were fed either a …
(WD) on cognitive dysfunction. Specific pathogen-free, wild-type mice were fed either a …
[HTML][HTML] The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology
B Li, SY Cai, JL Boyer - Biochimica et Biophysica Acta (BBA)-Molecular …, 2021 - Elsevier
Activated by retinoids, metabolites of vitamin A, the retinoic acid receptors (RARs) and the
retinoid X receptors (RXRs) play important roles in a wide variety of biological processes …
retinoid X receptors (RXRs) play important roles in a wide variety of biological processes …
[HTML][HTML] Retinoids in health and disease: a role for hepatic stellate cells in affecting retinoid levels
MW Haaker, AB Vaandrager, JB Helms - Biochimica et Biophysica Acta …, 2020 - Elsevier
Vitamin A (retinol) is important for normal growth, vision and reproduction. It has a role in the
immune response and the development of metabolic syndrome. Most of the retinol present …
immune response and the development of metabolic syndrome. Most of the retinol present …
Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose
Activation of extracellular matrix–producing hepatic stellate cells (HSCs) is a key event in
liver fibrogenesis. We showed that the expression of the heme-thiolate monooxygenase …
liver fibrogenesis. We showed that the expression of the heme-thiolate monooxygenase …
Genome-wide analysis of cis-regulatory changes underlying metabolic adaptation of cavefish
Cis-regulatory changes are key drivers of adaptative evolution. However, their contribution
to the metabolic adaptation of organisms is not well understood. Here, we used a unique …
to the metabolic adaptation of organisms is not well understood. Here, we used a unique …
[HTML][HTML] miR-22 inhibition reduces hepatic steatosis via FGF21 and FGFR1 induction
Background & Aims Metabolism supports cell proliferation and growth. Surprisingly, the
tumor suppressor miR-22 is induced by metabolic stimulators like bile acids. Thus, this study …
tumor suppressor miR-22 is induced by metabolic stimulators like bile acids. Thus, this study …