Simple Summary Poly (ADP-ribose) polymerase 1 (PARP1) is perhaps the most studied
member of the PARP superfamily and participates in numerous cellular processes. PARP1 …

Purpose of Review NAD+ is a vital molecule that takes part as a redox cofactor in several
metabolic reactions besides being used as a substrate in important cellular signaling in …

NAD+ is crucial for cellular balance in all organisms. Recent interest has focused on its
metabolism. Deficiency-related issues can be countered using NMN and NR, potential …

Nicotinamide riboside (NR) increases blood levels of NAD+, a cofactor central to energy
metabolism, and improves brain function in some rodent models of neurodegeneration. We …

Regulation of gene expression takes a central place in normal cells to maintain tissue
homeostasis but also in cancer cells to respond to intra-and extra-cellular stimuli, such as …

Disturbances in kidney tubular cell metabolism are increasingly recognized as a feature of
acute kidney injury (AKI). In AKI, tubular epithelial cells undergo abnormal metabolic shifts …

Bioenergetics plays a crucial role in sperm functions, including motility, capacitation‐related
protein modifications, oocyte recognition and interaction, all of which are essential for …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) is a crucial member of the PARP family,
which modifies targets through ADP-ribosylation and plays key roles in a variety of biological …

Cellular metabolism (or energetics) and epigenetics are tightly coupled cellular processes. It
is arguable that of all the described cancer hallmarks, dysregulated cellular energetics and …

Nuclear factor IB (NFIB) plays an important role in tumors. Our previous study found that
NFIB can promote colorectal cancer (CRC) cell proliferation in acidic environments …