Anaplastic thyroid cancer (ATC) is a rare malignancy. While external beam radiation therapy
has improved locoregional control, the median survival of∼ 4 months has not changed in …

It is now accepted that breast cancer is not a single disease, but instead it is composed of a
spectrum of tumor subtypes with distinct cellular origins, somatic changes, and etiologies …

Tumor progression is characterized by an incremental stiffening of the tissue. The
importance of tissue rigidity to cancer is appreciated, yet the contribution of specific tissue …

p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important
mediators of Rac and Cdc42 GTPase function as well as pathways required for Ras-driven …

The HER2 gene is an important prognostic and therapeutic marker in newly diagnosed
breast cancer. Currently, HER2 status is most frequently determined by …

The development of microarray technology has revolutionized RNA and deoxyribonucleic
acid (DNA) research. In contrast with traditional biological assays, microarrays allow the …

Chromosomal Instability (CIN) is a common and evolving feature in breast cancer. Large-
scale Transitions (LSTs), defined as chromosomal breakages leading to gains or losses of at …

Components of the tumour microenvironment initiate and promote cancer development. In
this study, we investigated the stromal component of parathyroid neoplasia …

The experimental method comparative genomic hybridization (CGH) array provides a full
picture of chromosome amplifications and deletions of an individual's genome. The multi …

BACKGROUND: Estrogen receptor (ER) remains one of the most important biomarkers for
breast cancer subtyping and prognosis, and comparative genome hybridization has greatly …