Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

The immune system is coordinated by an intricate network of stimulatory and inhibitory
circuits that regulate host responses against endogenous and exogenous insults. Disruption …

Inflammatory bowel disease (IBD) is a common inflammatory bowel disease with a high
incidence rate and serious consequences. Attempts in this area are focusing on developing …

Glycans are carbohydrates that are made by all organisms and covalently conjugated to
other biomolecules. Glycans cover the surface of both human cells and pathogens and are …

Galectins (Gals), a family of multifunctional glycan-binding proteins, have been traditionally
defined as β-galactoside binding lectins. However, certain members of this family have …

The intestine-specific transcription factor Cdx2 is essential for intestinal homeostasis and
has been implicated in the pathogenesis of disorders including inflammatory bowel disease …

Background Hepatocellular carcinoma (HCC) is one of the most malignant tumors
worldwide. The ST6 β-galactoside α-2, 6-sialyltransferase 1 (ST6GAL1) has been found …

Glycosylation has a profound influence on protein activity and cell biology through a variety
of mechanisms, such as protein stability, receptor interactions and signal transduction. In …

Ulcerative colitis (UC) is a chronic, relapsing inflammatory disease that affects human
intestines. Immune imbalance is one of the important factors inducing UC. After the …

Sialylation, a crucial post-translational modification of glycoconjugates, entails the
attachment of sialic acid (SA) to the terminal glycans of glycoproteins and glycolipids …