The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long
been used in cancer research. However, this system cannot be fully translated into clinical …

Ovarian cancer encompasses a heterogeneous group of malignancies that involve the
ovaries, fallopian tubes and the peritoneal cavity. Despite major advances made within the …

The lack of in vitro models that represent the native tumor microenvironment is a significant
challenge for cancer research. Two-dimensional (2D) monolayer culture has long been the …

In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …

The tumor microenvironment consists of diverse, complex etiological factors. The matrix
component of pancreatic ductal adenocarcinoma (PDAC) plays an important role not only in …

Ovarian cancer (OC) is one of the most common gynecological malignancies with high
morbidity and mortality. The peritoneum is one of the most common metastatic sites in …

Ovarian cancer rates the highest mortality among all gynecological malignancies. The main
reason for high mortality is the development of drug resistance. It can be related to changes …

Epithelial ovarian cancer (EOC) is considered the deadliest gynecological disease and is
normally diagnosed at late stages, at which point metastasis has already occurred …

The transmembrane serine protease matriptase is a key regulator of both barrier-disruptive
and protective epithelial cell–cell interactions. Elevated matriptase is a consistent feature of …

High-grade serous ovarian cancer (HGSOC) is the most frequent and aggressive type of
epithelial ovarian cancer, with high recurrence rate and chemoresistance being the main …