Main conclusion Plant tissue culture as an important tool for the continuous production of
active compounds including secondary metabolites and engineered molecules. Novel …

Virus-induced gene silencing (VIGS) has developed into an indispensable approach to
gene function analysis in a wide array of species, many of which are not amenable to stable …

Mammalian cell expression has become the dominant recombinant protein production
system for clinical applications because of its capacity for post-translational modification and …

Filovirus infections can cause a severe and often fatal disease in humans and nonhuman
primates, including great apes. Here, three anti-Ebola virus mouse/human chimeric mAbs …

Developing CRISPR/Cas9-mediated non-transgenic mutants in asexually propagated
perennial crop plants is challenging but highly desirable. Here, we report a highly useful …

Plant molecular farming (PMF) is a new branch of plant biotechnology, where plants are
engineered to produce recombinant pharmaceutical and industrial proteins in large …

Rapid, large‐scale manufacture of medical countermeasures can be uniquely met by the
plant‐made‐pharmaceutical platform technology. As a participant in the Defense Advanced …

No countermeasures currently exist for the prevention or treatment of the severe sequelae of
Filovirus (such as Ebola virus; EBOV) infection. To overcome this limitation in our biodefense …

Biologics are unaffordable to a large majority of the global population because of
prohibitively expensive fermentation systems, purification and the requirement for cold chain …

Plant viral vectors delivered by Agrobacterium are the basis of several manufacturing
processes that are currently in use for producing a wide range of proteins for multiple …