Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies

AC Marques, PJ Costa, S Velho, MH Amaral - Journal of controlled release, 2020 - Elsevier
Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells
in a safe and effective manner. Nanotechnology takes the lead in providing new therapeutic …

[HTML][HTML] Orientation and characterization of immobilized antibodies for improved immunoassays

NG Welch, JA Scoble, BW Muir, PJ Pigram - Biointerphases, 2017 - pubs.aip.org
Orientation of surface immobilized capture proteins, such as antibodies, plays a critical role
in the performance of immunoassays. The sensitivity of immunodiagnostic procedures is …

Synthesis, assembly, and applications of hybrid nanostructures for biosensing

S Zhang, R Geryak, J Geldmeier, S Kim… - Chemical …, 2017 - ACS Publications
The robust, sensitive, and selective detection of targeted biomolecules in their native
environment by prospective nanostructures holds much promise for real-time, accurate, and …

Antibody orientation on biosensor surfaces: a minireview

AK Trilling, J Beekwilder, H Zuilhof - Analyst, 2013 - pubs.rsc.org
Detection elements play a key role in analyte recognition in biosensors. Therefore, detection
elements with high analyte specificity and binding strength are required. While antibodies …

Protein-based bioactive coatings: from nanoarchitectonics to applications

C Fu, Z Wang, X Zhou, B Hu, C Li, P Yang - Chemical Society Reviews, 2024 - pubs.rsc.org
Protein-based bioactive coatings have emerged as a versatile and promising strategy for
enhancing the performance and biocompatibility of diverse biomedical materials and …

Site-directed antibody immobilization techniques for immunosensors

A Makaraviciute, A Ramanaviciene - Biosensors and Bioelectronics, 2013 - Elsevier
Immunosensor sensitivity, regenerability, and stability directly depend on the type of
antibodies used for the immunosensor design, quantity of immobilized molecules, remaining …

[HTML][HTML] Aptamers: active targeting ligands for cancer diagnosis and therapy

X Wu, J Chen, M Wu, JX Zhao - Theranostics, 2015 - ncbi.nlm.nih.gov
Aptamers, including DNA, RNA and peptide aptamers, are a group of promising recognition
units that can specifically bind to target molecules and cells. Due to their excellent specificity …

pH impacts the orientation of antibody adsorbed onto gold nanoparticles

G Ruiz, K Tripathi, S Okyem, JD Driskell - Bioconjugate chemistry, 2019 - ACS Publications
Novel detection strategies that exploit the unique properties of gold nanoparticles (AuNPs)
hold great promise for the advancement of diagnostic testing. Fundamental to many of these …

Quantifying bound and active antibodies conjugated to gold nanoparticles: A comprehensive and robust approach to evaluate immobilization chemistry

K Tripathi, JD Driskell - ACS omega, 2018 - ACS Publications
Gold nanoparticles (AuNPs) functionalized with antibodies have the potential to improve
biosensing technology because of the unique optical properties of AuNPs and the specificity …

Aptamers vs. antibodies as capture probes in optical porous silicon biosensors

S Arshavsky-Graham, K Urmann, R Salama… - Analyst, 2020 - pubs.rsc.org
Over the past decade aptamers have emerged as a promising class of bioreceptors for
biosensing applications with significant advantages over conventional antibodies. However …