[HTML][HTML] Happily (n) ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence

A Höhn, D Weber, T Jung, C Ott, M Hugo, B Kochlik… - Redox biology, 2017 - Elsevier
Aging is a complex phenomenon and its impact is becoming more relevant due to the rising
life expectancy and because aging itself is the basis for the development of age-related …

Causes of hyperhomocysteinemia and its pathological significance

J Kim, H Kim, H Roh, Y Kwon - Archives of pharmacal research, 2018 - Springer
In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease
and a definite risk factor for many other diseases. Homocysteine is biosynthesized from …

Trimethylamine N-oxide in relation to cardiometabolic health—cause or effect?

C Papandreou, M Moré, A Bellamine - Nutrients, 2020 - mdpi.com
Trimethylamine-N-oxide (TMAO) is generated in a microbial-mammalian co-metabolic
pathway mainly from the digestion of meat-containing food and dietary quaternary amines …

Hyperhomocysteinemia: clinical insights

F Al Mutairi - Journal of central nervous system disease, 2020 - journals.sagepub.com
Homocysteine (Hcy) is a sulfhydryl-containing amino acid, and intermediate metabolite
formed in metabolising methionine (Met) to cysteine (Cys); defective Met metabolism can …

Homocysteine and age-associated disorders

EA Ostrakhovitch, S Tabibzadeh - Ageing research reviews, 2019 - Elsevier
There are numerous theories of aging, a process which still seems inevitable. Aging leads to
cancer and multi-systemic disorders as well as chronic diseases. Decline in age-associated …

Global hearing loss prevention

CS Brown, SD Emmett, SK Robler… - … Clinics of North America, 2018 - oto.theclinics.com
Hearing loss affects individuals across all cultures; it is the fourth leading contributor to years
lived with a disability worldwide, 1 affecting 6% to 8% of the world's population. 2 Moreover …

Defective quality control autophagy in Hyperhomocysteinemia promotes ER stress and consequent neuronal apoptosis through proteotoxicity

B Kaur, PK Sharma, B Chatterjee, B Bissa… - Cell Communication and …, 2023 - Springer
Homocysteine (Hcy), produced physiologically in all cells, is an intermediate metabolite of
methionine and cysteine metabolism. Hyperhomocysteinemia (HHcy) resulting from an in …

Homocysteine fibrillar assemblies display cross-talk with Alzheimer's disease β-amyloid polypeptide

D Sade Yazdi, D Laor Bar-Yosef… - Proceedings of the …, 2021 - National Acad Sciences
High levels of homocysteine are reported as a risk factor for Alzheimer's disease (AD).
Correspondingly, inborn hyperhomocysteinemia is associated with an increased …

Choline metabolism and risk of atrial fibrillation and heart failure in the PREDIMED study

C Papandreou, M Bulló, P Hernández-Alonso… - Clinical …, 2021 - academic.oup.com
Background Few studies have examined the associations of trimethylamine-N-oxide (TMAO)
and its precursors (choline, betaine, dimethylglycine, and L-carnitine) with the risk of atrial …

G6PD overexpression protects from oxidative stress and age‐related hearing loss

JM Bermúdez‐Muñoz, AM Celaya… - Aging …, 2020 - Wiley Online Library
Aging of the auditory system is associated with the incremental production of reactive
oxygen species (ROS) and the accumulation of oxidative damage in macromolecules, which …