Renal denervation in the management of hypertension in adults. A clinical consensus statement of the ESC Council on Hypertension and the European Association of …

E Barbato, M Azizi, RE Schmieder… - European Heart …, 2023 - academic.oup.com
Since the publication of the 2018 European Society of Cardiology/European Society of
Hypertension (ESC/ESH) Guidelines for the Management of Arterial Hypertension, several …

Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension

QN Dinh, GR Drummond, CG Sobey… - BioMed research …, 2014 - Wiley Online Library
Hypertension is a complex condition and is the most common cardiovascular risk factor,
contributing to widespread morbidity and mortality. Approximately 90% of hypertension …

A controlled trial of renal denervation for resistant hypertension

DL Bhatt, DE Kandzari, WW O'Neill… - … England Journal of …, 2014 - Mass Medical Soc
Background Prior unblinded studies have suggested that catheter-based renal-artery
denervation reduces blood pressure in patients with resistant hypertension. Methods We …

Predictors of blood pressure response in the SYMPLICITY HTN-3 trial

DE Kandzari, DL Bhatt, S Brar… - European heart …, 2015 - academic.oup.com
Abstract Aims The SYMPLICITY HTN-3 randomized, blinded, sham-controlled trial confirmed
the safety of renal denervation (RDN), but did not meet its primary efficacy endpoint. Prior …

Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy

PS Chen, LS Chen, MC Fishbein, SF Lin… - Circulation …, 2014 - Am Heart Assoc
Autonomic nervous system activation can induce significant and heterogeneous changes of
atrial electrophysiology and induce atrial tachyarrhythmias, including atrial tachycardia and …

Obesity, hypertension, and chronic kidney disease

ME Hall, JM do Carmo, AA da Silva… - … journal of nephrology …, 2014 - Taylor & Francis
Obesity is a major risk factor for essential hypertension, diabetes, and other comorbid
conditions that contribute to development of chronic kidney disease. Obesity raises blood …

Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open …

M Azizi, M Sapoval, P Gosse, M Monge, G Bobrie… - The Lancet, 2015 - thelancet.com
Background Conflicting blood pressure-lowering effects of catheter-based renal artery
denervation have been reported in patients with resistant hypertension. We compared the …

Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies

K Sharma, DA Kass - Circulation research, 2014 - Am Heart Assoc
The clinical syndrome comprising heart failure (HF) symptoms but with a left ventricular
ejection fraction (EF) that is not diminished, eg, HF with preserved EF, is increasingly the …

Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study

H Krum, MP Schlaich, PA Sobotka, M Böhm, F Mahfoud… - The Lancet, 2014 - thelancet.com
Background Renal denervation (RDN) with radiofrequency ablation substantially reduces
blood pressure in patients with treatment-resistant hypertension. We assessed the long-term …

Expert consensus document from the European Society of Cardiology on catheter-based renal denervation

F Mahfoud, TF Lüscher, B Andersson… - European Heart …, 2013 - academic.oup.com
Hypertension is highly prevalent and one of the most frequent chronic diseases worldwide. 1
It has been suggested that over the next two decades up to 50% of the adult population will …