Immediately following the discovery of the structure of DNA and the semi-conservative
replication of the parental DNA sequence into two new DNA strands, it became apparent …

Pre-B-cell leukemia homeobox transcription factor 1 (PBX1) was first identified as part of a
fusion protein resulting from the chromosomal translocation t (1; 19) in pre-B cell acute …

Many stem cells undergo asymmetric division to produce a self-renewing stem cell and a
differentiating daughter cell. Here we show that, similarly to H3, histone H4 is inherited …

Cellular proliferation depends on the accurate and timely replication of the genome. Several
genetic diseases are caused by mutations in key DNA replication genes; however, it …

The replication-timing program constitutes a key element of the organization and
coordination of numerous nuclear processes in eukaryotes. This program is established at a …

Mechanosignaling, initiated by extracellular forces and propagated through the intracellular
cytoskeletal network, triggers signaling cascades employed in processes as embryogenesis …

Recent studies have attempted to develop molecular signatures of epithelial ovarian cancer
(EOC) based on the quantitation of protein-coding and non-coding RNAs to predict disease …

Both onco-suppressor PREP1 and the oncogene MEIS1 bind to PBX1. This interaction
stabilizes the two proteins and allows their translocation into the nucleus and thus their …

The ability of many proteins to fold into well-defined structures has been traditionally
considered a prerequisite for fulfilling their functions. Protein folding is also regarded as a …

Background: This study explored the effects and potential mechanism by which PBX/knotted
1 homeobox 1 (PKNOX1) may exacerbate stomach adenocarcinoma (STAD). Methods: For …