Metallodrugs are unique: Opportunities and challenges of discovery and development

EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …

Pt (II) and Au (III) complexes containing Schiff-base ligands: A promising source for antitumor treatment

Y Sun, Y Lu, M Bian, Z Yang, X Ma, W Liu - European Journal of Medicinal …, 2021 - Elsevier
The effective application of cisplatin in the clinic as an antitumor treatment has stimulated
widespread interest in inorganic metal drugs. In particular, complexes containing the …

Recent advances in Schiff base ruthenium metal complexes: synthesis and applications

A Singh, P Barman - Topics in Current Chemistry, 2021 - Springer
This review concentrates on recent developments in ruthenium Schiff bases, whose steric
and electronic characteristics can be manipulated easily by selecting suitable condensing …

Synthesis, characterization and anticancer activity of mono-and dinuclear Ni (II) and Co (II) complexes of a Schiff base derived from o-vanillin

H Bahron, SS Khaidir, AM Tajuddin, K Ramasamy… - Polyhedron, 2019 - Elsevier
Abstract A Schiff base ligand, 6, 6′-dimethoxy-2, 2′-[o-phenylenebis (nitrilomethylidyne)]
diphenolato (LA), and its mononuclear and dinuclear Ni (II) and Co (II) complexes were …

Biological response of Schiff base metal complexes incorporating amino acids–a short review

A Arunadevi, N Raman - Journal of Coordination Chemistry, 2020 - Taylor & Francis
Metal complexes have more biological activities than their corresponding ligands. In
particular, Schiff base complexes are of great interest due to their stability, electron donating …

Recent advances in anticancer ruthenium Schiff base complexes

S Parveen - Applied Organometallic Chemistry, 2020 - Wiley Online Library
Nowadays in cancer treatment, both metal complexes and organic molecules are being
widely used. Current years have seen a surge of interest in the application of organometallic …

Recent advances and future development of metal complexes as anticancer agents

P Jia, R Ouyang, P Cao, X Tong, X Zhou… - Journal of …, 2017 - Taylor & Francis
Since the initial discovery of applications of platinum complexes in the clinical treatment of
many kinds of cancers, the efficiency of platinum complexes in inhibiting the proliferation of …

Transition metal complexes with tridentate schiff bases (ONO and ONN) derived from salicylaldehyde: an analysis of their potential anticancer activity

LA Alfonso‐Herrera, S Rosete‐Luna… - …, 2022 - Wiley Online Library
Although it is known that the first case of cancer was recorded in ancient Egypt around 1600
BC, it was not until 1917 during the First World War and the development of mustard gas that …

Recent advances and therapeutic journey of Schiff base complexes with selected metals (Pt, Pd, Ag, Au) as potent anticancer agents: A review

S Khan, FA Alhumaydhi, MM Ibrahim… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
Schiff bases and their transition metal complexes play an important role in the field of
medicine, in particular in the treatment of cancer. Since the discovery of the cisplatin …

Synthesis, characterization, antimicrobial activity and DFT study of some novel Schiff bases

M Salihović, M Pazalja, SŠ Halilović, E Veljović… - Journal of molecular …, 2021 - Elsevier
Two new Schiff bases derived from L-cysteine and substituted benzaldehyde were
synthesized: the compound 1 [2-((2-chlorobenzylidene) amino)-3-mercaptopropanoic acid] …