Pyrimidine-based EGFR TK inhibitors in targeted cancer therapy
Despite significant improvements of new treatment options, cancer continues to represent as
one of the most common and fatal disease. The EGFR signaling pathway is considered as a …
one of the most common and fatal disease. The EGFR signaling pathway is considered as a …
Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy
KE Arnst, S Banerjee, H Chen, S Deng… - Medicinal research …, 2019 - Wiley Online Library
Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …
Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule …
R Romagnoli, F Prencipe, P Oliva… - Journal of Medicinal …, 2019 - ACS Publications
The clinical evidence for the success of tyrosine kinase inhibitors in combination with
microtubule-targeting agents prompted us to design and develop single agents that possess …
microtubule-targeting agents prompted us to design and develop single agents that possess …
A review on fused pyrimidine systems as EGFR inhibitors and their structure–activity relationship
TT Yadav, G Moin Shaikh, MS Kumar… - Frontiers in …, 2022 - frontiersin.org
Epidermal growth factor receptor (EGFR) belongs to the family of tyrosine kinase that is
activated when a specific ligand binds to it. The EGFR plays a vital role in the cellular …
activated when a specific ligand binds to it. The EGFR plays a vital role in the cellular …
Furo[2,3‐d]pyrimidines as Mackinazolinone/Isaindigotone Analogs: Synthesis, Modification, Antitumor Activity, and Molecular Docking Study
B Song, L Nie, K Bozorov, C Niu… - Chemistry & …, 2023 - Wiley Online Library
The chemical transformation of the tricyclic furo [2, 3‐d] pyrimidines was performed under
isosteric and scaffold‐hopping strategies focusing on the synthesis of its arylidene and imine …
isosteric and scaffold‐hopping strategies focusing on the synthesis of its arylidene and imine …
Pd(II)-Catalyzed Three-Component Synthesis of Furo[2,3-d]pyrimidines from β-Ketodinitriles, Boronic Acids, and Aldehydes
A Pd (II)-catalyzed three-component synthesis of 2, 4, 6-triarylfuro [2, 3-d] pyrimidines from β-
ketodinitriles, boronic acids, and aldehydes has been developed. The participation of both …
ketodinitriles, boronic acids, and aldehydes has been developed. The participation of both …
Synthesis and anticancer activities of diverse furo[2,3-d]pyrimidine and benzofuro[3,2-d]pyrimidine derivatives
X Tang, A Zheng, F Wu, C Liao, Y Hu… - Synthetic …, 2022 - Taylor & Francis
A series of diverse furo [2, 3-d] pyrimidines (2a–2b, 4a–4d and 8a–8c) and benzofuro [3, 2-d]
pyrimidines (12a–12c) were synthesized and screened for their antitumor effects against …
pyrimidines (12a–12c) were synthesized and screened for their antitumor effects against …
Coumarin–furo [2, 3-d] pyrimidone hybrid molecules targeting human liver cancer cells: synthesis, anticancer effect, EGFR inhibition and molecular docking studies
T Wang, Y Gao, F Wu, L Luo, J Ma, Y Hu - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
The design, synthesis and investigation of antitumor activities of some coumarin–furo [2, 3-d]
pyrimidone hybrid molecules are reported. In vitro, HepG2 cells were used to investigate the …
pyrimidone hybrid molecules are reported. In vitro, HepG2 cells were used to investigate the …
Copper (II) mediated C–H methylthiolation of 2-phenyl pyridines with dimethyl sulfoxide using an amino acid ligand
Y Xiao, S Wang, J Liu, H Zhang, Y Xu - Tetrahedron Letters, 2019 - Elsevier
A novel protocol for the C–H methylthiolation of 2-phenyl pyridines using DMSO as the
methylthio source and an amino acid ligand is described. This simple procedure requires …
methylthio source and an amino acid ligand is described. This simple procedure requires …
Radiosynthesis and evaluation of [11C] AG-488, a dual anti-angiogenetic and anti-tubulin PET ligand
JSD Kumar, A Molotkov, P Carberry, T Chaly… - Bioorganic & Medicinal …, 2022 - Elsevier
Combinations of antiangiogenic and cytotoxic agents show promising results in the
treatment of cancer. However, there is a lack of single agent with both antiangiogenic and …
treatment of cancer. However, there is a lack of single agent with both antiangiogenic and …