Inflammasomes are molecular platforms that assemble upon sensing various intracellular
stimuli. Inflammasome assembly leads to activation of caspase 1, thereby promoting the …

Depression and obesity are common conditions with major public health implications that
tend to co-occur within individuals. The relationship between these conditions is …

Crosstalk between inflammatory pathways and neurocircuits in the brain can lead to
behavioural responses, such as avoidance and alarm, that are likely to have provided early …

Animals receive environmental stimuli from neural signals in order to produce hormones that
control immune responses. Glucocorticoids (GCs) are a group of steroid hormones …

Microneedles technology is a powerful platform to achieve efficient transdermal delivery of
bioactive molecules for local or systemic therapies attributing to their minimally invasive …

We report a dissolvable microneedle (MN) patch that can mediate transdermal codelivery of
CRISPR-Cas9–based genome-editing agents and glucocorticoids for the effective treatment …

Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer
and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be …

Regulated cell death (RCD) is essential for successful systemic cancer therapy. Yet, the
engagement of RCD pathways does not inevitably result in cell death. Instead, RCD …

Advances in genomic research and risk-directed therapy have led to improvements in the
long-term survival and quality of life outcomes of patients with childhood acute lymphoblastic …