Abstract Purpose of Review We re-evaluated clinical applications of image-to-FE models to
understand if clinical advantages are already evident, which proposals are promising, and …

Simple Summary Major progress has been achieved in stage-IV bone metastatic patients to
control over the disease progression, thereby resulting in longer survival. Self-autonomy and …

Bone segmentation is an important step to perform biomechanical failure load simulations
on in-vivo CT data of patients with bone metastasis, as it is a mandatory operation to obtain …

Spine is the most common site for bone metastases. The evaluation of the mechanical
competence and failure location in metastatic vertebrae is a biomechanical and clinical …

Introduction: Pathologic vertebral fractures are devastating for patients with spinal
metastases. However, the mechanical process underlying these fractures is poorly …

This article presents an effort toward building an artificial intelligence (AI) assisted
framework, coined ReconGAN, for creating a realistic digital twin of the human vertebra and …

The structural performance of a vertebra can be significantly undermined if it develops a
tumour, that could even lead to the vertebra's structural collapse. In cancers with a high …

The evaluation of the local mechanical behavior as a result of metastatic lesions is
fundamental for the characterization of the mechanical competence of metastatic vertebrae …

Background Bone metastases may lead to spine instability and increase the risk of fracture.
Scoring systems are available to assess critical metastases, but they lack specificity, and …

Intervertebral disc (IVD) degeneration is suspected to affect the distribution of stress and
strain near the vertebral endplates and in the underlying bone. This scenario is worsened by …