[HTML][HTML] Extrachromosomal circular DNA in cancer: history, current knowledge, and methods
Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA
molecule found in all tested eukaryotes. eccDNA plays important roles in cancer …
molecule found in all tested eukaryotes. eccDNA plays important roles in cancer …
Small extrachromosomal circular DNA (eccDNA): major functions in evolution and cancer
X Ling, Y Han, J Meng, B Zhong, J Chen, H Zhang… - Molecular cancer, 2021 - Springer
Extrachromosomal circular DNA (eccDNA) refers to a type of circular DNA that originate from
but are likely independent of chromosomes. Due to technological advancements, eccDNAs …
but are likely independent of chromosomes. Due to technological advancements, eccDNAs …
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma
Circular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of
oncogenic gene expression, evolution of drug resistance and poor patient outcomes …
oncogenic gene expression, evolution of drug resistance and poor patient outcomes …
The role of the core non-homologous end joining factors in carcinogenesis and cancer
DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …
Extrachromosomal circular DNA: biogenesis, structure, functions and diseases
L Yang, R Jia, T Ge, S Ge, A Zhuang, P Chai… - Signal transduction and …, 2022 - nature.com
Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base
pairs, is independent of conventional chromosomes. Recently, eccDNAs have been …
pairs, is independent of conventional chromosomes. Recently, eccDNAs have been …
The molecular origins and pathophysiological consequences of micronuclei: New insights into an age-old problem
Micronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can
exist in cells with numerical and/or structural chromosomal aberrations in apparently normal …
exist in cells with numerical and/or structural chromosomal aberrations in apparently normal …
Extrachromosomal DNA in cancer
V Bafna, PS Mischel - Annual review of genomics and human …, 2022 - annualreviews.org
In cancer, complex genome rearrangements and other structural alterations, including the
amplification of oncogenes on circular extrachromosomal DNA (ecDNA) elements, drive the …
amplification of oncogenes on circular extrachromosomal DNA (ecDNA) elements, drive the …
[HTML][HTML] Extrachromosomal DNA—relieving heredity constraints, accelerating tumour evolution
Highlights•Extrachromosomal DNA (ecDNA) provides a mechanism by which cancer cells
can accelerate intratumour heterogeneity.•ecDNA contain favourable epigenetic …
can accelerate intratumour heterogeneity.•ecDNA contain favourable epigenetic …
Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance
Y Yan, G Guo, J Huang, M Gao, Q Zhu, S Zeng… - Journal of Hematology & …, 2020 - Springer
Extrachromosomal circular DNA was recently found to be particularly abundant in multiple
human cancer cells, although its frequency varies among different tumor types. Elevated …
human cancer cells, although its frequency varies among different tumor types. Elevated …
Extrachromosomal circular DNA (eccDNA): an emerging star in cancer
Extrachromosomal circular DNA (eccDNA) is defined as a type of circular DNA that exists
widely in nature and is independent of chromosomes. EccDNA has attracted the attention of …
widely in nature and is independent of chromosomes. EccDNA has attracted the attention of …