G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …

Mitochondrial dysfunction has consequences not only for cellular energy output but also for
cellular signaling pathways. Mitochondrial dysfunction, often based on inherited gene …

Oncodriver genes are usually identified when mutations recur in multiple tumours. Different
drivers often converge in the activation or repression of key cancer-relevant pathways …

Background: Considering protein mutations in their biological context is essential for
understanding their functional impact, interpretation of high-dimensional datasets and …

Genome sequencing efforts, coupled with technological advances and cost reductions, have
led to the discovery of an increasing number of disease-related genetic variants. For the vast …

Genetic variants are currently a major component of system-wide investigations into
biological function or disease. Approaches to select variants (often out of thousands of …

Abstract The Precision Oncology (PO) approach uses data from next-generation genome
sequencing of tumors to select therapy for oncologic patients independently of the type of …