Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with
age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal …

Regulated fibroblast growth factor (FGF) signalling is a prerequisite for the correct
development and homeostasis of articular cartilage, as evidenced by the fact that aberrant …

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive erosion of
articular cartilage. As chondrocytes are the only cell type forming the articular cartilage, their …

Osteoarthritis (OA), characterized by chondrocyte apoptosis and disturbance of the balance
between catabolism and anabolism of the extracellular matrix (ECM), is the most common …

Osteoarthritis is a common joint disease for which there are currently no disease-modifying
drugs available. Degradation of the cartilage extracellular matrix is a central feature of the …

Osteoarthritis afflicts millions of individuals across the world resulting in impaired quality of
life and increased health costs. To understand this disease, physicians have been studying …

Human cartilage is a complex tissue of matrix proteins that vary in amount and orientation
from superficial to deep layers and from loaded to unloaded zones. A major challenge to …

Members of the transforming growth factor beta (TGFβ) superfamily of secreted factors play
essential roles in nearly every aspect of cartilage formation and maintenance. However, the …