The ITP syndrome: pathogenic and clinical diversity

DB Cines, JB Bussel, HA Liebman… - Blood, The Journal of …, 2009 - ashpublications.org
Immune thrombocytopenia (ITP) is mediated by platelet autoantibodies that accelerate
platelet destruction and inhibit their production. Most cases are considered idiopathic …

The pathogenesis of immune thrombocytopaenic purpura

N Cooper, J Bussel - British journal of haematology, 2006 - Wiley Online Library
Immune thrombocytopaenic purpura (ITP) is an autoimmune bleeding disease that is rarely
fatal. However, in many adults treatment is unsatisfactory, with as much morbidity from the …

Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing

SL Smith, PR Kennedy, KB Stacey… - Blood …, 2020 - ashpublications.org
Children with immune thrombocytopenia (ITP) rarely suffer from life-threatening bleeds (eg,
intracranial hemorrhage). In such settings, the combination of IV methylprednisolone (IVMP) …

Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents

W Bao, JB Bussel, S Heck, W He… - Blood, The Journal …, 2010 - ashpublications.org
Immune thrombocytopenia (ITP) is an autoantibody-mediated bleeding disorder with both
accelerated platelet destruction and impaired platelet production. We and others have …

Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response

FP Panitsas, M Theodoropoulou, A Kouraklis… - Blood, 2004 - ashpublications.org
Derangement of cellular immunity is central in the pathophysiology of adult
autoimmune/idiopathic thrombocytopenic purpura (ITP). Herein we investigated cytokine …

Intravenous immunoglobulin: an update on the clinical use and mechanisms of action

VS Negi, S Elluru, S Siberil, S Graff-Dubois… - Journal of clinical …, 2007 - Springer
Initially used as a replacement therapy for immunodeficiency diseases, intravenous
immunoglobulin (IVIg) is now widely used for a number of autoimmune and inflammatory …

High-dose intravenous immunoglobulins in the treatment of severe acute viral pneumonia: the known mechanisms and clinical effects

X Liu, W Cao, T Li - Frontiers in immunology, 2020 - frontiersin.org
The current outbreak of viral pneumonia, caused by novel coronavirus SARS-CoV-2, is the
focus of worldwide attention. The WHO declared the COVID-19 outbreak a pandemic event …

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell–mediated responses that are differentially sensitive to therapy

L Chow, R Aslam, ER Speck, M Kim… - Blood, The Journal …, 2010 - ashpublications.org
Immune thrombocytopenia (ITP) is a bleeding disorder characterized by antibody-opsonized
platelets being prematurely destroyed in the spleen, although some patients with ITP may …

Cell‐mediated lysis of autologous platelets in chronic idiopathic thrombocytopenic purpura

F Zhang, X Chu, L Wang, Y Zhu, L Li… - European journal of …, 2006 - Wiley Online Library
Objectives: Investigate the contribution and mechanism of cell‐mediated cytotoxicity to the
pathogenesis of idiopathic thrombocytopenic purpura (ITP). Methods: We observed the …

Modulation of the cellular immune system by intravenous immunoglobulin

T Tha-In, J Bayry, HJ Metselaar, SV Kaveri… - Trends in …, 2008 - cell.com
Intravenous immunoglobulin (IVIg) is therapeutically used in a variety of immune-mediated
diseases. The beneficial effects of IVIg in auto-antibody-mediated diseases can be …