ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Abstract National Institute on Aging–Alzheimer's Association definition and classification of
sporadic Alzheimer's disease (sAD) is based on the assumption that β‐amyloid drives the …

Understanding age acceleration, the discordance between biological and chronological
age, in the brain can reveal mechanistic insights into normal physiology as well as elucidate …

In this review, we comprehensively, qualitatively, and critically synthesized several features
of APOE-e2, a known APOE protective variant, including its associations with longevity …

Background: Alzheimer's disease neuropathologic change (ADNC) is defined by the
progression of both hyperphosphorylated-tau (p-tau) and amyloid-(A) and is the most …

Abstract Alzheimer's disease (AD)-related neurofibrillary tangles (NFT), argyrophilic grain
disease (AGD), aging-related tau astrogliopathy (ARTAG), limbic predominant TDP-43 …

Alzheimer disease is one of the most challenging demons in our society due to its very high
prevalence and its clinical manifestations which cause deterioration of cognition …

Abstract Introduction Neurofibrillary degeneration in Alzheimer's disease (AD) typically
involves the entorhinal cortex and CA1 subregion of the hippocampus early in the disease …

Aims Few studies have investigated primary age‐related tauopathy (PART) in a population‐
based setting. Here, we assessed its prevalence, genetic background, comorbidities and …

Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is the most prevalent monogenic cerebral small‐vessel …