Surgery is an important treatment modality for the majority of solid organ cancers.
Unfortunately, cancer recurrence following surgery of curative intent is common, and …

In patients with cancer, opioids are principally used for the management of acute surgical
and chronic cancer‐related pain. However, opioids have many non‐analgesic effects …

Preclinical and clinical studies have sought to better understand the effect of anesthetic
agents, both volatile and intravenous, and perioperative adjuvant medications on immune …

Purpose Mortality among cancer patients is more commonly due to the effects of metastasis
and recurrence as opposed to the primary tumour. Various perioperative factors have been …

Mast cells are tissue-resident immune cells that release immuno-modulators, chemo-
attractants, vasoactive compounds, neuropeptides and growth factors in response to …

Background Morphine stimulates angiogenesis and cancer progression in mice. We
investigated whether morphine influences tumour onset, development, and animal model …

The feasibility of OFA is evident. However, there are limitations of this approach that warrant
discussion including the potential for adverse drug interactions with multimodal analgesics …

Background We and others have previously demonstrated that the μ-opioid receptor (MOR)
is overexpressed in several human malignancies. There is a seven-fold increase in MOR in …

Background Opioid-induced immunomodulation may be of particular importance in triple-
negative breast cancer (TNBC) where an immune response is associated with improved …

Preclinical studies have demonstrated that opioid receptor agonists increase the rate of non‐
small cell lung cancer (NSCLC) growth and metastasis. Following institutional review board …